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Naturopathic Support for Cancer

Naturopathic Support for Cancer

Q: I have recently been diagnosed with cancer. How can Naturopathic Medicine help me?

 

A: Over 80% of people with cancer are choosing to use naturopathic medicine alongside their conventional treatments. Naturopathic Doctors (NDs) provide evidence-informed guidance on safe and effective use of natural and supportive therapies, when combined with standard treatments. Naturopathic physicians use a variety of therapies, which include clinical nutrition, botanical medicine, acupuncture, intravenous treatments and lifestyle counseling. Combining conventional medicine and naturopathic medicine can support the pursuit of best possible outcomes for patients.

With this approach, quality of life can be improved and the patient is supported for optimal health and well-being: physically, mentally and emotionally. NDs use natural and supportive therapies to try to reduce side effects, support conventional care, and prevent recurrence. These therapies may require a variety of approaches, namely intravenous treatments and supplements. Based on the type of cancer or the side effects of the chemotherapy or radiation treatment, there are a wide range of Naturopathic supplements and individualized intravenous treatments to improve the quality of life for a patient. Please reach out to us and book in your appointment – we will be happy to assist you find the right treatment plan.

Dr. Sanjay Mohan Ram, BSc, ND has been supporting patients with various forms of cancer since 2004. He is booking telemedine and in-person consults Tuesdays and Fridays.

Hair Loss in Women

Hair Loss in Women

For women, hair has always been considered as one of the most important outward signs of beauty.  Billions of dollars are spent each year on styling, colouring, and nourishing those luscious locks.  A good or bad hair day can make or break our mood and few things cause more distress than the thought of losing our hair. However, more than 50% of women will experience significant hair loss by the age of 50. Female pattern hair loss (FPHL) is characterized by diffuse hair thinning, typically over the crown of the head and temporal regions, with retention of the frontal hairline, though variations of this pattern do occur.  Unlike male pattern hair loss, which is predominantly due to increased androgen activity and genetically determined, FPHL is more complex and multi-faceted.  

 

Life Cycle of Hair:

All of our hair follicles are formed before birth—by about week 22 of fetal development.  At this stage, there are roughly 1 million hair follicles on the scalp, representing the maximum number we will ever have, as we unfortunately do not regenerate follicles at any point during our lives. 

There are three phases of hair growth.  Anagen is the active phase, where a new hair is formed and grows about 1cm every month. Follicles typically stay in this phase for anywhere from 2-7 years. Catagen is a transitional phase in which the hair stops growing and its outer sheath attaches to the root of the hair to form a ‘club hair’.  Telogen is the resting phase of the follicle, which lasts for about 3 months for scalp hair. Shedding is normal during the telogen phase, averaging up to around 100 hairs per day.  This number can increase greatly during telogen effluvium, a type of temporary hair loss brought on by a shock to the system such as stress, surgery, or other traumatic event. At any given time, around 85% of follicles are in the anagen phase.  Anything that shortens the anagen phase will affect the thickness and length of hair, and premature entry and prolongation of telogen leads to increased hair loss.  Permanent hair loss results when follicles transition from producing thick, pigmented terminal hairs to short, fine, unpigmented vellus hair—a phenomenon known as miniaturization.

 

Causes of Hair Loss:

 

Genetics:

Upwards of 200 genes affect the characteristics of human hair, including its colour, texture, curl, and susceptibility to hair loss, androgenetic or otherwise.  Thus, hair loss is almost always multifactorial, especially for women, and must be addressed as such.  

 

Medications:

Hair loss is a very common but often overlooked side effect of a number of commonly prescribed medications. The most likely culprits are blood pressure medications such as beta-blockers and ACE inhibitors, cholesterol-lowering drugs such as statins, and antidepressants including bupropion (Wellbutrin) and SSRIs such as fluoxetine (Prozac), sertraline (Zoloft), and paroxetine (Paxil).  These medications typically cause the type of hair loss known as telogen effluvium, which can take 2-4 months to become noticeable.  The good news is that this type of hair loss is reversible. Oral contraceptives can also affect hair growth.

 

Scalp health:

The overall health of the scalp also affects the health of the hair follicles.  Dandruff, a common problem, can indicate simple dryness of the skin, fungal infections, or other skin disorders that affect hair growth.  Autoimmune diseases such as psoriasis can also lead to significant hair loss. 

 

Nutrient deficiencies:

The rapidly dividing cells of the active follicle require many nutrients to produce healthy hair and many nutrient deficiencies have been linked with hair loss.  These include minerals such as iron, zinc, copper, manganese, and magnesium, as well as various B vitamins, Vitamin D, and Vitamin C. Conversely, excess levels of heavy metals like lead and cadmium can have a detrimental effect.

 

Underlying medical conditions:

Hair health is a good indicator of overall health, thus hair loss is often a signal of an underlying medical condition.  Both hypo- and hyperthyroid states can cause hair loss, particularly in the case of Hashimoto’s disease, an autoimmune condition.  Other autoimmune diseases that can affect the hair follicles include alopecia areata, psoriasis, lupus, and Crohn’s disease.  

 

Various hormonal changes can also affect hair growth.  In women, this is particularly evident with pregnancy, where many women notice a marked increase in hair growth, only to have it fall out post-partum, sometimes to below pre-pregnancy levels.   Estrogen and progesterone levels decline significantly after menopause, corresponding with an increase in the frequency and severity of hair loss. The most common hormonal cause of hair loss, in both women and men, is excess androgen activity due to a form of testosterone known as dihydrotestosterone (DHT).  Testosterone is converted to DHT by the enzyme 5-alpha-reductase, which is present in the hair follicles.  Overactivity of this enzyme can lead to high levels of DHT, even when testosterone levels are normal.  Thus, many treatments are aimed at inhibiting the activity of 5-alpha-reductase.  Women with polycystic ovarian syndrome (PCOS) often experience hair loss, along with other symptoms of hyperandrogenism such as hirsutism, acne, and irregular periods. 

 

Treatment of FPHL:

 

The basic principles of naturopathic medicine emphasize finding the root cause of a condition and treating the whole person.  Hair loss is often a symptom of an underlying problem which must be addressed.  Lab testing can identify simple nutrient deficiencies, anemia, or thyroid issues.  With FPHL, complete hormone panels are often necessary to identify imbalances.  These can include testosterone, DHT, DHEA, estradiol, progesterone, cortisol, and thyroid hormones, to name a few.  Treatments can include diet and lifestyle modifications, nutritional supplements, topical treatments, prescription medications, and more.  

 

Nutrition:

Robust hair growth requires many nutrients, thus a nutritious, well-balanced diet is essential, as is a healthy gut capable of digesting and absorbing those nutrients.  Any deficiencies identified through testing must be corrected.  Common supplements to promote keratin formation and follicle health in FPHL include zinc, biotin, manganese, and silica. 

 

Hormone balancing:

  • Androgens: elevated DHT levels are often addressed by inhibiting the 5-alpha-reductase enzyme.  Finasteride is the standard prescription medication for men, but its use is contraindicated for women of child-bearing age due to its potential effects on development of a male fetus.  In post-menopausal women, finasteride has been used off-label for FPHL with a success rate of roughly 50%.  Many herbs can also be used to lower DHT activity.  These include Serenoa repens (saw palmetto), Urtica dioica (nettle), Trifolium pretense (red clover), Pygeum africanum, and Polygonum multiflorum, to name just a few.  
  • Insulin: high insulin levels have been associated with both male and female pattern hair loss, due at least partly to its influence on androgen levels. Diet modifications to manage blood sugar levels and insulin resistance are therefore very important.  Supplementation with inositol has been shown to decrease symptoms of insulin resistance and androgen excess and is a common treatment for PCOS. Herbs such as Humulus (hops) and Gymnema can also be helpful. 
  • Progesterone: progesterone acts as an antagonist to DHT, therefore low levels can exacerbate the effects of DHT.  Low progesterone levels can also stimulate production of the adrenal hormone androstenedione which itself has some androgenic activity. The best-known herb for increasing progesterone is Vitex agnus-castus.  Bioidentical progesterone may also be prescribed, particularly peri- or postmenopausally, to increase progesterone levels.

 

Topical treatments:

Because the hair outside the follicle is dead, any treatment of the shaft itself (i.e. shampoos, conditioners) is purely cosmetic. Topical treatments must reach the follicle in order to be effective.  

 

  • Minoxidil: The most common prescription medication is minoxidil (best known as Rogaine).  Initially introduced as a blood pressure medication, minoxidil acts primarily by increasing circulation in the scalp.  It helps to both activate resting follicles and to keep follicles in the active phase longer.  It can be difficult to apply and requires twice a day dosing to be effective. Newer formulations of minoxidil include tretinoin (a form of Vitamin A) which acts synergistically, and a small amount of an anti-inflammatory corticosteroid such as fluocinolone.  This underscores the role inflammation can play in promoting hair loss, both at the follicular and systemic levels.  
  • Melatonin: topical application of melatonin (1% solution) has been used in the treatment of FPHL and appears to decrease hair loss by increasing anagen rates.
  • Essential oils: numerous essential oils have been used traditionally to treat hair loss for centuries.  A combination of thyme, rosemary, lavender, and cedarwood massaged into the scalp daily has been shown to be effective in the treatment of alopecia areata.

 

Non-chemical treatments:

  • Low level laser therapy: also known as photobiomodulation or photobiostimulation, these treatments are thought to stimulate hair follicles by improving mitochondrial oxidative metabolism and activating transcription factors to promote transition from telogen to anagen.
  • Platelet-Rich Plasma (PRP): in this treatment, the patient’s own blood is drawn then spun in a centrifuge to isolate a serum fraction rich in platelets, which contain abundant growth factors and cytokines responsible for regeneration and repair.  This PRP is injected into the scalp to help stimulate hair regrowth.

 

Dr. Susan Goto, ND

 

References

 

Attia P, host. “Alan Bauman, M.D.: The science of male and female hair restoration.” The Peter Attia Drive, episode 43, 04 March 2019, https://peterattiamd.com/alanbauman/.

Chan L, Cook D. Female Pattern Hair Loss. Austr J Gen Prac. 2018; 47(7): 459-464.

Cho CH, Bae JS, Kim YU. 5alpha-reductase inhibitory components as antiandrogens from herbal medicine. J Acupunct Meridian Stud. 2010;3(2):116-118.

Fischer TW, Burmeister G, Schmidt HW, Elser P. Melatonin increases anagen hair rate in women with androgenic alopecia or diffuse alopecia: results of a pilot randomized controlled trail. Br J Dermatol. 2004;150(2):341-345.

Hay I, Jamieson M, Ormerod A. Randomized trial of aromatherapy: successful treatment for alopecia areata. Arch Dermatol. 1998;134(11):1349-1352.

Justicz N, Derakshan A, Chen JX, Lee LN. Platelet-Rich Plasma for Hair Restoration. Facial Plast Surg CLin North Am. 2020; 28(2): 181-187.

Loing E, Lachance R, Ollier V. A new strategy to modulate alopecia using a combination of two specific and unique ingredients. J Cosmet Sci. 2013;64(1):45-58.

The Skinny on Intermittent Fasting

The Skinny on Intermittent Fasting

You’ve probably heard about intermittent fasting which, according to Google, was the most searched diet trend of 2019.  The practice of fasting has been around since ancient times. Hippocrates, widely considered the father of modern medicine, was a staunch supporter.  Fasting for spiritual purposes is widely practiced and is a component of virtually every major religion in the world, considered to be a cleansing and purifying process for both the body and the spirit. Numerous studies suggest intermittent fasting has a beneficial effect on a wide range of chronic disorders including cardiovascular disease, diabetes, cancer, autoimmunity, and neurodegenerative brain diseases such as Alzheimer’s and Parkinson’s.  But can it also help us lose weight and, more importantly, keep the weight off permanently?

 

What is intermittent fasting?

The basic principle of intermittent fasting is simple: abstain from eating during specific time periods and eat during others. The 3 most common variations are:

 

  1. Daily time-restricted eating: this involves eating all your meals for the day within a certain window of time, typically anywhere from 4-12 hours (meaning you’ll be fasting for 12-20 hours of the day). For example, if you stop eating by 8 p.m. then have your first meal at noon, you will have created a 16-hour fasting state.
  2. Alternate day fasting: this involves alternating “feed days”, where you eat normally, with “fast days”, where eating is restricted to one meal of ~500 calories, ideally consisting of protein, healthy fats, and vegetables (i.e. no refined starches or sugars)
  3. 5:2 intermittent fasting: in this plan, you eat normally five days of the week and drastically reduce calories on the other two days, typically 500 calories for women and 600 calories for men.

Which plan is best for you?  There is no single right answer and in fact, most people find it beneficial to switch things up periodically.  In general, it is recommended to start slowly and gradually increase your fasting window in order to avoid unpleasant side effects that can discourage you from continuing.  There is some evidence to suggest that timing your eating window earlier in the day, say from 8a.m. to 2 p.m., can help normalize cortisol expression and circadian rhythms. 

 

How does intermittent fasting work?

 

Calorie reduction:


At its most superficial level, intermittent fasting can reduce the total number of calories we consume.  Although there are no specific calorie limits set, restricting our eating to a limited number of hours naturally tends to limit the amount of food we eat, particularly in the evenings when many of us plunk ourselves down on the couch to watch TV while mindlessly munching on high calorie, highly processed snack foods. 

 

Facilitates ketosis:

In a prolonged fasting state, once the body has used up its reserves of glucose, it starts burning fat for fuel. Decreasing the body’s excess fat stores, particularly the visceral fat deposits (around the abdominal organs) is integral to healthy and long-lasting weight loss.

 

Metabolism boost:

One common misconception that makes many people reluctant to try fasting is the idea that it causes our basal metabolism to decrease—the so-called “starvation mode”, making it harder to lose weight in the long run. In fact, fasting causes an increase in metabolic rate, mediated by an increase in adrenaline as well as growth hormone.  Presumably, this serves as an adaptive response to give us the energy to go out and find food in times of scarcity.  Humans as a species would not have survived very long if the body’s response to missing a few meals was to shut down completely. Growth hormone also helps the body utilize fat for fuel and preserve muscle mass and bone density.  Ironically, daily calorie reduction, not fasting, does in fact lead to decreased metabolism, as the body matches lower food intake with lower energy expenditure.  When food intake goes to zero, however, the body switches its energy source from ingested food to its own stored fat reserves which provide ample energy for maintaining metabolism.  Alternating between a fed state and a fasting state is therefore more important than simply reducing overall calories. 

 

Decreased insulin and insulin resistance:

The root cause of obesity in many cases is persistently high levels of insulin leading to insulin resistance, increased fat storage, and a higher body weight set point.  The body weight set point is monitored by the hypothalamus but appears to be set higher by higher levels of insulin.  When we attempt to lose weight by the standard method of eating less and exercising more, the hypothalamus acts to maintain the set point by decreasing our energy expenditure (by decreasing metabolic rate, body temperature, etc) and increasing appetite. Therefore, further weight loss becomes more and more difficult, and over time we tend to regain that weight and then some.  Breaking the insulin-resistance cycle and lowering the body weight set point to allow long-term weight loss requires recurrent periods of very low insulin levels. Since all food stimulates an insulin response to some degree (with refined starches and sugars being the worst offenders), the best way to achieve this is via fasting. 

 

Contraindications for fasting

Although intermittent fasting can be a powerful tool for losing weight and improving overall health, it is not for everyone. Women who are pregnant or breastfeeding should not practice intermittent fasting so as not to compromise their baby’s nutritional needs.  Likewise, children under 18 should not fast for extended periods, nor should anyone underweight (e.g. body mass index (BMI) less than 18.5).  The strict eating schedule may also act as a trigger for those with a history of anorexia or other eating disorder.  

Individuals taking medications, especially diabetics, must exercise caution and require medical supervision when undertaking an intermittent fasting program, as does anyone with pre-existing medical conditions such as kidney disease, cardiovascular disease, and adrenal issues. 

Susan Goto, ND

 

References:

De Cabo, R, Mattson, MP. Effects of Intermittent Fasting on Health, Aging, and Disease. N Engl J Med, 2019, 381(26): 2541-2551.

Ferrannini E, Natali A, Bell P, et al. Insulin resistance and hypersecretion in obesity. J Clin Invest. 1997 Sep 1; 100(5):1166–73.

Harvie MN et al. The effects of intermittent or continuous energy restriction on weight loss and metabolic disease risk markers. Int J Obes (Lond). 2011 May; 35(5):714–27.

Heilbronn LK. Alternate-day fasting in nonobese subjects: effects on body weight, body composition, and energy metabolism. Am J Clin Nutr. 2005; 81:69–73.

Jamshed, H; Beyl, RA; Della Manna, DL; Yang, ES; Ravussin, E; Peterson, CM. Early Time-Restricted Feeding Improves 24-Hour Glucose Levels and Affects Markers of the Circadian Clock, Aging, and Autophagy in Humans. Nutrients, 2019, 11, 1234. 

Leibel RL, Hirsch J. Diminished energy requirements in reduced-obese patients. Metabolism. 1984 Feb; 33(2):164–70.

Lustig R. Hypothalamic obesity: causes, consequences, treatment. Pediatr Endocrinol Rev. 2008 Dec; 6(2):220–7.

Stubbs RJ et al. Effect of an acute fast on energy compensation and feeding behaviour in lean men and women. Int J Obesity. 2002 Dec; 26(12):1623–8.